Can Blades in the Dark be played in a custom setting?


I’m looking at systems for my next campaign. Currently I really like the look of Blades in the Dark however I have one concern before I invest in buying the rulebook.

Every review of the system I have read talks about how great the setting of Duskvol is and how much of the world building is done for you. It also seems that some of the playbooks and factions are heavily tied to the setting. Particularly the ghosts seem integral to the system.

Ideally I wanted to use this system in a homebrew city within my own world that I currently use to run a pathfinder game. My setting wouldn’t have ghost and would likely be a lower technology level than the default setting.

How well does Blades in the Dark adapt to a custom setting?