Can we use multiple framework (both front end and back end) to build a website?


I am a newbie ( HTML CSS/ zero level ) to web development and when I search the internet there are literally tonnes of web framework for both front end and backend development. Like Django, PHP, NodeJs, ReactJs, VueJs etc.

So can anyone please sort out best framework and also one of my major doubt is Can I built or use different framework simultaneously to build a website (front end and back end) OR Should I possibly learn some from above list and do my work with it ( That means we cannot use multiple language at once like Djanog PHP and Nodejs etc togther).

If we can do so , building a website with multiple framework possess any advantage or it will be fairly difficult manage..