Choosing the Ability for a Hex

The Hex spell allows afflicting a target with a Disadvantage on Ability checks. I’m having a hard time deciding which Ability to target when hexing a target. What factors are there that should influence my choice in favour of a given Ability during a typical combat?

I understand that no choice is perfect, but I would still like to understand whether (or when) a given choice is usually good (e.g. due to some check being commonly and usefully exploitable by almost any party), situationally good (e.g. in combination with a given class/subclass/build, and/or when facing certain types of enemies), or usually bad (due to lacking meaningful ways to capitalise on it).