How can a low level rouge reduce a targets constitution bonus

I want to play a rogue that relies heavily on poisons and other utility flasks (ie: alchemists fire). We’re starting out at level 1 and the story arc should take us to roughly level 11. To make poisons more reliable, how would you go about reducing a targets constitution so that there is a better chance that the target has a better chance at failing their saving roll?

In Battle? Out of Battle?