Is the Chronicles of Darkness line suitable for play with a Story Teller and two players?

I have a group of three players, but more often than not real-life stuff means that only two are available to play at any particular time. I’ve recently had my curiosity piqued by the New World of Darkness/Chronicles of Darkness lines but have read varying advice as to how well the system/style would work with mainly two, occasionally 3 players.

Is the Chronicles of Darkness system suitable for two players and a Story Teller?

Please note – valid answers to this question must draw on personal experience.