$NP$, $P^{TFNP}$ and $P^{UP}$

Is it possible

  1. $ NP\in P^{TFNP}$ holds or

  2. $ NP\in P^{UP}$ holds

without the polynomial hierarchy collapsing?

Is there problems in

  1. one of each of the classes from $ NP$ , $ P^{UP}$ and $ P^{TFNP}$ but not in other two?

  2. two of each pair of the classes from $ NP$ , $ P^{UP}$ and $ P^{TFNP}$ but not in last?