Uses of irreducible control flow

What are some applications where irreducible control flow is required*?

I’m particularly interested in programming language features that will be tricky to efficiently compile if the compile target does not permit irreducible control flow. For example, a programming language offering GOTO will generate irreducible control flow for some programs. What other language constructs are like this? For example, is irreducible control flow required to implement resumable exceptions?

I’m also interested in application-level uses of irreducible control flow.

(*: irreducible control flow graphs (CFGs) can be converted to reducible CFGs at some cost, and also some compiler optimizations can convert reducible CFGs to irreducible CFGs, so what I mean is that the original, unoptimized CFG produced by the source code is irreducible. Less formally, I mean that the "programmer’s intent" naturally includes irreducible control flow)